Principles of Forensic Toxicology. Second Edition. Barry Levine. Working in a clinical chemistry or toxicology. Principles of Forensic Toxicology. The first section provides an introduction to postmortem forensic toxicology, human performance forensic toxicology, forensic drug testing, and pharmacokinetics and pharmacodynamics. The second section is devoted to analytical principles, including both theory and applications.

Thermal Design And Optimization Adrian Bejan Pdf Creator. This is the second edition of a book intended as a text for students taking a one-semester course in forensic toxicology or as a desk reference source for laboratorians. The book consists of 22 chapters written by 20 contributors, most of whom are well-recognized authorities in this field.

The overall organization of the book remains unchanged, with the chapters grouped into three sections: Part I (Introduction), Part II (Methodologies), and Part III (Analytes). Parts I and II comprise approximately one-half the book and Part III the remaining half. The first three chapters, Postmortem Forensic Toxicology, Human Performance Toxicology, and Forensic Drug Testing, present an overview of each of these subdisciplines of forensic toxicology and address legal, preanalytical, analytical, and postanalytical issues associated with each area. Chapter 4, Pharmacokinetics and Pharmacodynamics, presents a concise but relatively complete discussion of the principles of pharmacokinetics and nicely illustrates their application to the practice of forensic toxicology by use of several case histories. Part II contains five chapters covering Specimen Preparation, Spectrophotometry, Chromatography, Immunoassay, and Mass Spectrometry. These chapters focus on the analytical methods used in the analysis of drugs and toxins, including the underlying scientific principles, strengths, and limitations of these methods.

Part III is divided into 13 chapters covering Alcohol, CNS Depressants, Opioids, Cocaine, Marijuana, Amphetamines/Sympathomimetic Amines, Hallucinogens, Anticonvulsant and Antiarrhythmic Drugs, Antidepressant Drugs, Neuroleptic Drugs, Carbon Monoxide/Cyanide, Inhalants, and Metals. These provide a nice overview of each of the major classes of toxic substances encountered by the forensic toxicologist. The information presented includes source; nomenclature; chemical structure; structure–activity relationships; mechanism of action; effects; pharmacokinetics; concentrations encountered in blood, urine, and other body fluids; preanalytical and analytical considerations; and interpretation of results. Compared with the first edition of 1999, the most noticeable change is the addition of two new chapters: Anticonvulsant and Antiarrhythmic Drugs and Neuroleptic (Antipsychotic) Drugs. In spite of these additional chapters, this second edition is nine pages shorter than the first because of increased print density and a substantial size reduction for most of the figures and tables. Several of the chapters have been updated; for example, the chapter on alcohol now contains a section on legal and regulatory applications, and information on γ-hydroxybutyrate (GHB) and ketamine has been added to the chapters on central nervous system depressants and hallucinogens, respectively. The material presented appears to be appropriate for a graduate, or upper-level undergraduate, introductory course in forensic toxicology.

This book would also be useful as a review tool for those studying for board certification examinations in toxicology or as a quick desk reference for laboratorians working in a clinical chemistry or toxicology laboratory who are frequently consulted with questions about overdoses and poisonings. • © 2004 The American Association for Clinical Chemistry.